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KMID : 1149220210290020093
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Korean Journal of Oriental Medical Prescription
2021 Volume.29 No. 2 p.93 ~ p.103
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Intraocular Pressure and Neuroprotective Effect of water and ethanol extracts from Leaves of Acer palmatum thumb. of glaucoma in DBA2/J mice
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Oh Tae-Woo
Park Kwang-Il
Ma Jin-Yeul
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Abstract
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Objectives : This study was conducted to evaluate the Intraocular pressure (IOP) and retina neuroprotective effect of Acer palmatum thumb. extract in glaucoma of DBA2/J mice vivo model.
Methods : The amount of change in intraocular pressure(IOP) was measured every two weeks for 30 weeks in the DBA2/J glaucoma animal model. The increased IOP were regrouping into drug treatment groups. EW and EE (1, 2 ㎎/㎖)extract was eye drop administered twice per day for 8 weeks. After administration of the extract, IOP was measured every 1 week at a fixed time for 8 weeks, and protein expression levels and serological changes related to retinal function were investigated.
Results : The DBA2/J mice were IOP increased as time dependent, resulting in damage to the retinal function protein related in glaucoma animal model. However, administration of extracts from Leaves of Acer palmatum thumb. prevented an increase IOP, increased for Brn3α, PKCα, and OPN1SW. Additionally, the experssion of Aterocyte maker, GFAP was decreased in DBA2/J mice.
Conclusions : These results demonstrate that both IOP and age can be considered in studies using DBA2/J mice and suggest that the extracts from Leaves of Acer palmatum thumb. regulating of IOP and expression of proteins related to retinal function.
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KEYWORD
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DBA2/J, Glaucoma, Intraocular pressure(IOP), Retina, Acer palmatum thumb
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